Copper-catalyzed cross dehydrogenative coupling reactions of tertiary amines with ketones or indoles |
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| Authors: | Yang Fei Li Jian Xie Jin Huang Zhi-Zhen |
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| Affiliation: | Key Laboratory of Mesoscopic Chemistry of MOE, College of Chemistry, and Chemical Engineering, Nanjing University, Nanjing 210093, PR China. |
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| Abstract: | A novel cross dehydrogenative coupling (CDC) reaction of N,N-dimethylanilines with methyl ketones by cooperative copper and aminocatalysis has been developed, which leads to the formation of β-arylamino ketones in 42-73% yields. Moreover, the copper-catalyzed alkylation of free (NH) indoles with N,N-dimethylanilines via CDC reaction is also presented, affording alkylated indoles in 52-78% yields. |
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