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Preparation of poly(vinylpyrrolidone)-protected Prussian blue nanoparticles-modified electrode and its electrocatalytic reduction for hemoglobin |
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| Authors: | Yuezhong Xian Yuyan Zhou Lihui Zhou Litong Jin |
| Affiliation: | a Department of Chemistry, East China Normal University, Shanghai 200062, PR China b State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, PR China c Center of Analysis and Research, East China University of Science and Technology, Shanghai 2000237, PR China |
| Abstract: | In this paper, a novel modified electrode was developed by using highly dispersed Prussian blue (PB) nanoparticles protected by poly(vinylpyrrolidone) (PVP). The size of the nanoparticles was controlled through adjusting the feed ratio of PVP/Fe2+. Physical characteristics of the nanocomposite were studied by transmission electron microscopy (TEM), UV-vis, IR spectroscopy, and X-ray powder diffraction (XRPD) analysis. The electrocatalytic reduction of hemoglobin (Hb) at PVP-protected PB nanoparticles (PVP/PB NPs)-modified electrode had been investigated. In addition, the size effects and biocompatibility of PVP/PB NPs for the electrochemistry of Hb were also observed. Experimental results indicated that the reduction peak currents of Hb were linear with its concentrations over the range from 1.0 × 10−7 to 1.2 × 10−5 mol/L and the calculated detection limit (S/N = 3) was 4.0 × 10−8 mol/L. |
| Keywords: | Prussian blue (PB) nanoparticles Poly(vinylpyrrolidone) (PVP) Electrochemical catalysis Hemoglobin (Hb) |
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