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Electrochemical DNA biosensors based on platinum nanoparticles combined carbon nanotubes
Authors:Ningning Zhu  Pingang He
Institution:a Department of Chemistry, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, China
b Department of Chemistry, East China Normal University, Shanghai 200062, China
Abstract:Platinum nanoparticles were used in combination with multi-walled carbon nanotubes (MWCNTs) for fabricating sensitivity-enhanced electrochemical DNA biosensor. Multi-walled carbon nanotubes and platinum nanoparticles were dispersed in Nafion, which were used to fabricate the modification of the glassy carbon electrode (GCE) surface. Oligonucleotides with amino groups at the 5′ end were covalently linked onto carboxylic groups of MWCNTs on the electrode. The hybridization events were monitored by differential pulse voltammetry (DPV) measurement of the intercalated daunomycin. Due to the ability of carbon nanotubes to promote electron-transfer reactions, the high catalytic activities of platinum nanoparticles for chemical reactions, the sensitivity of presented electrochemical DNA biosensors was remarkably improved. The detection limit of the method for target DNA was 1.0 × 10−11 mol l−1.
Keywords:Carbon nanotubes  Platinum nanoparticles  Electrochemical DNA biosensor
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