Towards the development of multisensor for drugs of abuse based on molecular imprinted polymers |
| |
Authors: | Elena V Piletska Maria Romero-Guerra Iva Chianella Kal Karim Anthony PF Turner Sergey A Piletsky |
| |
Institution: | Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire MK45 4DT, UK |
| |
Abstract: | The synthetic receptors for cocaine, deoxyephedrine, methadone and morphine were computationally designed and produced using molecular imprinting. The structure and energy of the molecular complexes were analysed by computational techniques. The possible structures of the binding sites in the synthetic receptors have been compared with those of corresponding natural receptors. The composition of imprinted polymers was optimised to allow adequate performance under the same experimental conditions. All selected molecular imprinting polymers (MIPs) demonstrated stronger affinity in comparison with corresponding blank polymers resulting in imprinted factors (I) equal to 1.2 (cocaine), 2.5 (deoxyephedrine), 3.5 (methadone) and 3 (morphine) which suggested that the specific binding site for each molecule was successfully created. The polymers studied possessed good selectivity and affinity towards their templates and could be recommended for the integration with sensor devices. From a practical point of view, especially for multisensor requirements, the synthetic receptors based on imprinted polymers could be superior to natural receptors due to their stability, robustness and compatibility with automation processes required for sensor fabrication. |
| |
Keywords: | Cocaine Deoxyephedrine Methadone Morphine Molecular imprinting Molecular modelling HPLC Sensor |
本文献已被 ScienceDirect 等数据库收录! |
|