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Constituents of regenerated plants of Ophiorrhiza pumila; formation of a new glycocamptothecin and predominant formation of (3R)-deoxypumiloside over (3S)-congener |
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| Authors: | Mariko Kitajima,Mio Nakamura,Hiromitsu Takayama,Kazuki Saito,Joachim Stö ckigt,Norio Aimi |
| Affiliation: | a Faculty of Pharmaceutical Sciences, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263, Japan b Institute of Pharmacy, Johannes Gutenberg-Universität Mainz, Staudinger Weg 5, 55099, Mainz, Germany |
| Abstract: | The regeneration of plantlets was successful from Ophiorrhiza pumila callus cultures, from which a new glucosyloxy camptothecin, 9-β-glucosyloxycamptothecin, together with 15 metabolites including six camptothecin-related alkaloids was isolated. (3S)-Deoxypumiloside, one of the plausible biogenetic precursors of camptothecin, could not be found, whereas the (3R) epimer was isolated from the regenerated plants. |
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