Synthesis and preliminary biodistribution studies of [131I]SIB-PEG4-CHC in tumor-bearing mice |
| |
| Authors: | Xiaobei Zheng Feng Dong Jing Yang Xiaojiang Duan Tingting Niu Wangsuo Wu Jianjun Wang |
| |
| Affiliation: | (1) Radiochemistry Lab, School of Nuclear Science and Technology, Lanzhou University, Lanzhou, 730000, China;(2) Department of Nuclear Medicine, Gansu Academy of Medical Sciences, Lanzhou, 730050, China; |
| |
| Abstract: | This work reports the synthesis and preliminary biodistribution results of [131I]SIB-PEG4-CHC in tumor-bearing mice. The tributylstannyl precursor ATE-PEG4-CHC was synthesized by conjugation of ATE to amino pegylated colchicine NH2-PEG4-CHC. [131I]SIB-PEG4-CHC was radiosynthesized by electrophilic destannylation of the precursor with a yield of ~44%. The radiochemical purity (RCP) appeared to be >95% by a Sep-Pak cartridge purification. [131I]SIB-PEG4-CHC was lipophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that [131I]SIB-PEG4-CHC cleared from background rapidly, and didn’t deiodinate in vivo. However, the poor tumor localization excluded it from further investigations as a tumor-targeted radiopharmaceuticals. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
