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肉芝软珊瑚Sarcophyton crassocaule中新的多羟基甾醇的分离
引用本文:张翠仙,阎素君,张广文,苏镜娱,曾陇梅. 肉芝软珊瑚Sarcophyton crassocaule中新的多羟基甾醇的分离[J]. 高等学校化学学报, 2007, 28(4): 686-688
作者姓名:张翠仙  阎素君  张广文  苏镜娱  曾陇梅
作者单位:中山大学化学与化工学院,广州,510275;广州中医药大学中药学院,广州,510405;中山大学化学与化工学院,广州,510275;暨南大学食品科学与工程系,广州,510632
基金项目:国家自然科学基金 , 国家高技术研究发展计划(863计划)
摘    要:报道了从三亚海域的一种肉芝软珊瑚Sarcophyton crassocaule Mosre中分离得到2个多羟基甾醇1和2. 通过波谱分析等方法测定了它们的化学结构, 化合物1为新化合物, 命名为Sarcrasterol. 化合物2为已知物[24ξ-methyl-colestane-3β,5β,6α,25-tetrol], 但其C24构型未确定, 通过X射线单晶衍射分析测定了其相对构型为24S.

关 键 词:肉芝软珊瑚  次生代谢产物  多羟基甾醇  细胞毒性
文章编号:0251-0790(2007)04-0686-03
收稿时间:2006-05-06
修稿时间:2006-05-06

Isolation of New Polyhydroxylated Sterol from Soft Coral Sarcophyton crassocaule Mosre
ZHANG Cui-Xian,YAN Su-Jun,ZHANG Guang-Wen,SU Jing-Yu,ZENG Long-Mei. Isolation of New Polyhydroxylated Sterol from Soft Coral Sarcophyton crassocaule Mosre[J]. Chemical Research In Chinese Universities, 2007, 28(4): 686-688
Authors:ZHANG Cui-Xian  YAN Su-Jun  ZHANG Guang-Wen  SU Jing-Yu  ZENG Long-Mei
Affiliation:1. School of Chemistry and Chemical Engineering , Sun Yat Sen University, Guangzhou 510275, China; 2. School of Taditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China ; 3. Department of Food Science and Technology, Jinan University, Guangzhou 510632, China
Abstract:In our continuing search of discovering bioactive substances from marine organisms, a sample of soft coral Sarcophyton crassocaule Mosre collected off the Sanya bay, China, was investigated. Two polyhydroxylated sterols 1 and 2 were isolated from the 95% ethanol extract of the sample by chromatography over silica gel. Compound 1, named sarcrasterol, was a new compound, its structure was established as(22R*,24ξ)-methyl-cholest-5-en-3β,22α,25,28-tetraol by spectroscopic methods. Compound 2, a known compound, was first obtained by Kobayashi, however, the relative configuration of C24 has not been determined yet. This paper reports the stereochemistry of compound 2 established as (24S*)-methyl cholest-3β,5β,6α,25-tetraol by means of X-ray single crystal diffraction analysis. Bioassay results show that compound 2 has a moderate activity against human tumor cell lines MGC-803 with an IC50 value of 23.0 μg/mL.
Keywords:Soft coral  Sarcophyton crassocaule  Polyhydroxylated sterols  Cytotoxicity
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