Studies on antiatherosclerotic agents. Synthesis and inhibitory activities on platelet aggregation of 4-aryl derivatives of 7-ethoxycarbonyl-6,8-dimethyl-1 (2H)-phthalazinone. |
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| Authors: | Y Eguchi Y Sato S Sekizaki M Ishikawa |
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| Affiliation: | Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan. |
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| Abstract: | 4-Aryl derivatives of 7-ethoxycarbonyl-6,8-dimethyl-1(2H)-phthalazinone and related derivatives were newly synthesized in order to test for their inhibitory activities on platelet aggregation. 4-(2-Anisyl) compound and the corresponding 1-chloro derivative demonstrated significant activity. |
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