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Highly efficient glucosylation of flavonoids |
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| Authors: | Volodymyr Semeniuchenko Yana Garazd Myroslav Garazd Tetyana Shokol Ulrich Groth and Volodymyr Khilya |
| Institution: | (1) Fachbereich Chemie und Konstanz Research School Chemical Biology, Universit?t Konstanz, Universit?tsstrasse 10, Fach 720, 78457 Constance, Germany;(2) Department of Chemistry, National Taras Shevchenko University, Kiev, Ukraine;(3) Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine |
| Abstract: | AbstractA highly efficient procedure for glucosylation of flavonoids by acetobromoglucose is described. Glucosylation is carried out in a two-phase system CHCl3/H2O over 96 h using tetrabutylammonium bromide as phase-transfer catalyst. A purification procedure can be performed without column chromatography, and the yields of the glucosylated flavonoids are mostly quantitative. Acetylated glucosides were deprotected with sodium methanolate to afford the desired glucosides of flavonoids. |
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