Modular synthesis of mono, di, and tri-1,4-disubstituted-1,2,3-triazoles through copper-mediated alkyne-azide cycloaddition |
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| Authors: | Hé lio A. Stefani,Hugo A. CanduziniFlá via Manarin |
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| Affiliation: | Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, SP, Brazil |
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| Abstract: | The synthesis of 1,2,3-triazoles was developed employing sequential copper azide-alkyne cycloaddition, tosylation, sodium azide, and copper azide-alkyne steps. This approach allowed the synthesis of two and three 1,2,3-triazole rings. A preliminary study to gain further insight into the reaction was performed using in situ ReactIR technology. |
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| Keywords: | Click chemistry 1,2,3-Triazole Cycloaddition Propargyl alcohol Ultrasound |
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