| 新型含吡唑基3,4-二氢嘧啶类化合物的一锅合成研究 |
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| 引用本文： | 刘锦贵,王国辉,党珊. 新型含吡唑基3,4-二氢嘧啶类化合物的一锅合成研究[J]. 应用化学, 2009, 26(10): 1206-1210 |
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| 作者姓名： | 刘锦贵 王国辉 党珊 |
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| 作者单位： | (河南师范大学化学与环境科学学院 新乡 453007) |
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| 基金项目： | 河南省教育厅自然科学基金 |
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| 摘 要： | 以FeCl3•6H2O为催化剂，无水乙醇为溶剂，按取代-4-甲酰基吡唑：乙酰乙酸乙酯：（硫）脲：FeCl3•6H2O =1：3：3：1的比例，采取微波辐射和常规加热回流的方法通过Biginelli缩合反应一锅合成了6种新型含吡唑基的3,4-二氢嘧啶类化合物，并进行了元素分析、IR、1H-NMR和13C-NMR表征。
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| 关 键 词： | 三氯化铁，Biginelli缩合反应，二氢嘧啶，一锅合成，微波辐射 |
| 收稿时间： | 2008-10-15 |
| 修稿时间： | 2009-01-07 |
The study on the One-pot synthesis of Novel Pyrazol-3,4-Dihydropyrimidine |
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| LIU Jin-Gui,WANG Guo-Hui,DANG Shan. The study on the One-pot synthesis of Novel Pyrazol-3,4-Dihydropyrimidine[J]. Chinese Journal of Applied Chemistry, 2009, 26(10): 1206-1210 |
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| Authors: | LIU Jin-Gui WANG Guo-Hui DANG Shan |
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| Affiliation: | (College of Chemistry and Environmental Science,Henan Normal University,Xinxiang 453007) |
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| Abstract: | Pyrazol-3,4-dihydropyrimidines were synthesized by one-pot Biginelli cyclocondensation of substituted-4-formylpyrazole， ethyl acetoacetate， urea or thiourea and ferric choride(in molar ratio of 1∶ 3∶ 3∶ 1) in ethanol, under traditional heating or microwave irradiation conditions, while ferric chloride was used as a catalyst. The structures of all the products were characterized by elemental analysis, IR, ~1H NMR and ~(13)C NMR. The mechanism of the reaction and the spectra of all the compounds were also discussed. The method of microwave irradiation showed some advantages, such as a shorter reaction time and a higher yield, which is a new approach for synthesizing this kind of compounds. |
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| Keywords: | ferric chloride Biginelli condensation dihydropyrimidine one-pot synthesis microwave irradiation |
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