Synthesis of biaryl compounds using tandem ruthenium-catalyzed ring-closing metathesis |
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| Authors: | Yoshida Kazuhiro Shida Hiroaki Takahashi Hidetoshi Yanagisawa Akira |
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| Affiliation: | Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. kyoshida@faculty.chiba-u.jp |
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| Abstract: | Tandem ring-closing enyne metathesis (RCEM)/ring-closing olefin metathesis (RCM) of tetraenynes with Grubbs second-generation catalyst, followed by elimination, was found to be a new and efficient synthetic approach to biaryl compounds. A preliminary asymmetric version of this approach, which used homochiral Ru-alkylidene catalysts, is also presented. |
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| Keywords: | aromatic compounds asymmetric synthesis metathesis ring closure synthesis design |
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