| 海藻酸改性的空心Fe3O4纳米颗粒的制备与应用 |
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| 引用本文： | 董丽娟,金谷.海藻酸改性的空心Fe3O4纳米颗粒的制备与应用[J].化学物理学报,2015,28(2):193-196. |
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| 作者姓名： | 董丽娟 金谷 |
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| 作者单位： | 浙江工商大学食品科学与生物技术学院，杭州 310018,中国科学技术大学化学系，合肥 230026 |
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| 摘 要： | 不使用任何模板一步制得空心Fe3O4纳米颗粒，然后将海藻酸钠嫁接在氨基化的空心Fe3O4表面，再利用海藻酸盐与钙离子的作用，在空心Fe3O4表面形成一个凝胶化层，制得海藻酸盐凝胶化的空心Fe3O4纳米颗粒，粒径约为400～500 nm．采用TEM、XRD、XPS、VSM等手段对纳米微球进行表征．VSM表征结果表明在室温下样品磁性材料为超顺磁性．改性Fe3O4纳米颗粒成功地用于柔红霉素的载负和缓释，最大载负率和载药量分别为28.4%和14.2%．缓释结果表明，海藻酸盐凝胶化层的存在，能更有效控制柔红霉素缓慢地释放．
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| 关 键 词： | 空心Fe3O4纳米颗粒 APTMs 海藻酸盐 药物载体 |
| 收稿时间： | 2014/11/2 0:00:00 |
Alginate-Coated Fe3O4 Hollow Microspheres for Drug Delivery |
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| Li-juan Dong and Gu Jin.Alginate-Coated Fe3O4 Hollow Microspheres for Drug Delivery[J].Chinese Journal of Chemical Physics,2015,28(2):193-196. |
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| Authors: | Li-juan Dong and Gu Jin |
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| Institution: | College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China |
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| Abstract: | Novel hollow Fe3O4 nanoparticles for drug delivery were synthesized via a one-step templatefree approach. These nanoparticles were obtained by modifing the Fe3O4 nanoparticles with 3-aminopropyltrimethoxy silane, and then grafting alginate onto the surface of amine magnetic. The hollow structure of Fe3O4 spheres was characterized by TEM, XRD, and XPS. The M-H hysteresis loop indicated that the magnetic spheres exhibit superparamagnetic characteristics at room temperature. Daunorubicin acting as a model drug was loaded into the carrier, and the maximum percent of envelop and load were 28.4% and 14.2% respectively. The drug controlled releasing behaviors of the carriers were compared in different pH media. |
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| Keywords: | Hollow Fe3O4 nanoparticles 3-Aminopropyltrimethoxy silane Drug delivery |
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