| Synthesis and Characterization of Chitosan-g-poly- （D, L-lactic acid） Copolymer |
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| 引用本文： | HuaYANG ShaoBingZHOU XianMoDENG. Synthesis and Characterization of Chitosan-g-poly- （D, L-lactic acid） Copolymer[J]. 中国化学快报, 2005, 16(1): 123-126 |
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| 作者姓名： | HuaYANG ShaoBingZHOU XianMoDENG |
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| 作者单位： | ChengduInstituteofOrganicChemistry,ChineseAcademyofSciences.Chengdu610041 |
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| 摘 要： | Biodegradable chitosan-g-poly (D, L-lactic acid) copolymers were prepared via two methods. (1) The lactide was grafted onto hydroxyl groups of chitosan by using macromolecular initiator sodium of trimethylsilyl-chitosan, (2) poly (D,L-lactic acid)(PLA) with low molecular weight can be linked to the amino group by coupling activated PLA to trimethylsilyl-chitosan. Two graft copolymers had hydrophilic-hydrophobic character and can be applied as carriers for drug delivery.
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| 关 键 词： | 合成 表征 壳聚糖-g-聚（D L-乳酸） 接枝共聚物 大分子引发剂 聚合反应 |
Synthesis and Characterization of Chitosan-g-poly(D, L-lactic acid) Copolymer |
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| Hua YANG?,Shao Bing ZHOU,Xian Mo DENG Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu. Synthesis and Characterization of Chitosan-g-poly(D, L-lactic acid) Copolymer[J]. Chinese Chemical Letters, 2005, 16(1): 123-126 |
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| Authors: | Hua YANG? Shao Bing ZHOU Xian Mo DENG Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu |
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| Affiliation: | Hua YANG?,Shao Bing ZHOU,Xian Mo DENG Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041 |
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| Abstract: | Biodegradable chitosan-g-poly (D, L-lactic acid) copolymers were prepared via two methods. (1) The lactide was grafted onto hydroxyl groups of chitosan by using macromolecular initiator sodium of trimethylsilyl-chitosan, (2) poly (D,L-lactic acid)(PLA) with low molecular weight can be linked to the amino group by coupling activated PLA to trimethylsilyl-chitosan. Two graft copolymers had hydrophilic-hydrophobic character and can be applied as carriers for drug delivery. |
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| Keywords: | Poly (D L-lactic acid) chitosan graft copolymer coupling macromolecular initiator. |
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