| 格氏试剂异构偶联法合成辅酶Q10 |
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| 引用本文： | 李全,古昆,程晓红. 格氏试剂异构偶联法合成辅酶Q10[J]. 有机化学, 2005, 25(11): 1494-1497 |
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| 作者姓名： | 李全 古昆 程晓红 |
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| 作者单位： | 云南大学应用化学系,生物制药创新人才培养基地,昆明,650091 |
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| 摘 要： | 报道了一种利用2-甲基-3-氯-4-(2'-甲基-3',4',5',6'-四甲氧基苯)丁烯的格氏试剂与茄尼基溴发生异构偶联, 再氧化合成辅酶Q10的新方法. 发现了烯丙式格氏试剂与卤代烷经过六元环过渡态的异构偶联反应.
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| 关 键 词： | 辅酶Q10 茄尼醇 格氏试剂 异构偶联 |
| 收稿时间： | 2005-03-15 |
| 修稿时间： | 2005-09-05 |
Synthesis of Coenzyme Q10 via Isocoupling Reaction between Allylic Grignard Reagent and Allyl Halides |
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| LI,Quan,GU,Kun,CHENG,Xiao-Hong. Synthesis of Coenzyme Q10 via Isocoupling Reaction between Allylic Grignard Reagent and Allyl Halides[J]. Chinese Journal of Organic Chemistry, 2005, 25(11): 1494-1497 |
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| Authors: | LI Quan GU Kun CHENG Xiao-Hong |
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| Affiliation: | Department of Applied Chemistry, Yunnan University, Kunming 650091 |
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| Abstract: | Coenzyme Q10 was synthesized by the isocoupling reaction between Grignard reagent of 2-methyl-3-chloro-4-(2'-methyl-3',4',5',6'-tetramethoxyphenyl)butene and solanesyl bromide followed by oxidation of the corresponding toluene derivative. It is therefore successfully indicated that allylic Grignard reagent can be isocoupled with allyl halide via a six-membered ring as transition state. |
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| Keywords: | coenzyme Q10 solanesol Grignard reagent isocoupling |
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