| Enzyme-catalyzed direct three-component aza-Diels–Alder reaction using lipase from Candida sp.99–125 |
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| 作者姓名： | Dong-Hang Yin Wei Liu Zhi-Xiang Wang Xin Huang Jing Zhang De-Chun Huang |
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| 作者单位： | a Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing 210009, China;
b Department of Energy and Mechanical Engineering, Nanjing Normal University, Nanjing 210042, China |
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| 基金项目： | This research was supported in part by the Natural Science Foundation of Jiangsu Province (No. BK2012763) and the Fundamental Research Funds of the Central Universities from the Ministries of Education and Finance of China (No. ZD2014YX0027). |
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| 摘 要： | The direct three-component aza-Diels–Alder reaction was conducted with lipase as a catalyst for the first time. Under the optimized conditions, the aza-Diels–Alder reaction catalyzed by lipase from Candida sp.99–125 provided the products in moderate to excellent yields. Meanwhile, the endo/exo ratio reached up to 88:12.
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Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using lipase from Candida sp. 99-125 |
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| Dong-Hang Yin,Wei Liu,Zhi-Xiang Wang,Xin Huang,Jing Zhang,De-Chun Huang.Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using lipase from Candida sp. 99-125[J].Chinese Chemical Letters,2017,28(1):153-158. |
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| Authors: | Dong-Hang Yin Wei Liu Zhi-Xiang Wang Xin Huang Jing Zhang De-Chun Huang |
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| Institution: | a Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing 210009, China;
b Department of Energy and Mechanical Engineering, Nanjing Normal University, Nanjing 210042, China |
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| Abstract: | The direct three-component aza-Diels-Alder reaction was conducted with lipase as a catalyst for the first time. Under the optimized conditions, the aza-Diels-Alder reaction catalyzed by lipase from Candida sp. 99-125 provided the products in moderate to excellent yields. Meanwhile, the endo/exo ratio reached up to 88:12. |
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| Keywords: | Aza-Diels-Alder reaction Lipase Catalysis Candida sp 99-125 Azabicyclo [2 2 2] octan-5-one |
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