Cell microarray chip system for accurate,rapid diagnosis and target treatment of breast cancer cells SK-BR-3 |
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| Authors: | Ting Wang Yu Deng Guanwen Qu Yaozhong Chen Jing Shang Zhangqi Feng Jie Zheng Fengyu Yang Nongyue He |
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| Institution: | 1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China;2. Department of Chemical and Biomolecular Engineering, The University of Akron, Akron OH 44325, United States;3. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China;4. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;5. Nanjing Daniel New Mstar Technology Ltd., Nanjing 211200, China;6. National Demonstration Center for Experimental Biomedical Engineering Education, Southeast University, Nanjing 210096, China;1. Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;2. Department of Quality Assurance, Jiangsu Yangnong Chemical Group Co., Ltd., Yangzhou 225009, China;1. Department of Orthopedics, The Second Affiliated Hospital of Xi''an Jiaotong University, Xi''an, Shaanxi Province, 710004, PR China;2. Weihai City Key Laboratory of Autoimmunity of Weihai Central Hospital, Weihai, Shandong Province, 264400, PR China;1. State Key Laboratory of Bioelectronics, National Demonstration Centre for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China;2. State Key Laboratory of Natural Medicines, Department of Pharmacology, China Pharmaceutical University, Nanjing 210002, China;3. Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, OH 44325, United States;4. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;5. Nanjing Daniel New Mstar Technology Ltd., Nanjing 211200, China;1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China;2. National Centre for Nanoscience and Technology, Beijing 100190, China |
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| Abstract: | Breast cancer is one of the most common cancers in the world, survival rates of breast cancer are rising as screening and treatment improve. Many new technologies applied in the biomedical domain have been born for rapid diagnosis and treatment. In this work, visualization cell microarray chip with threedimensional (3D) embedded cell scaffold for cell diagnosis and treatment was designed. DNA segment, targeting on breast cancer cells SK-BR-3, were modified with camptothecin and used as model drug. Cell microarray chip system successfully control the diffusion of small molecules and locally introduced the compounds into cells. 3D embedded cell scaffold in the cell array chip afforded an environment with continuous medium supplementary and help controlling the diffusion of small molecules drugs. By cell microarray chip system, SK-BR-3 was targeted screening and killing in one step. Cell microarray chip system can achieve accurate, rapid diagnosis and target treatment of breast cancer cells SK-BR-3 and have a potential to develop to be an effective and accurate drug screen method for evaluating the drug effect of the booming chemicals. |
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| Keywords: | Cell micro-array chip DNA segment Target SK-BR-3 Camptothecin |
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