Fluorescent and colorimetric immunoassay of nuclear matrix protein 22 enhanced by porous Pd nanoparticles |
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| Authors: | Wenyun Zhuge Xiaofeng Tan Ruyue Zhang He Li Gengxiu Zheng |
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| Institution: | School of Chemistry and Chemical Engineering, University of Jinan, Ji'nan 250022, China |
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| Abstract: | A modified ELISA realizing fluorescent and colorimetric immunoassay of nuclear matrix protein 22 (NMP 22) was developed based on porous Pd nanoparticles. The unique structure and excellent enzyme mimetic activity of porous Pd nanoparticles favor to oxidize o-phenylenediamine (OPD) into 2,3-phenazinediamine (oxOPD) by H2O2, producing colorimetric and fluorescence dual-readout signal for the detection of NMP 22. The developed immunoassay method will offer great potential in clinical research and diagnostic applications. |
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| Keywords: | Nuclear matrix protein 22 Porous Pd nanoparticles ELISA Colorimetric Fluorescence |
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