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Continuous-flow synthesis of nitriles from aldehydes via Schmidt reaction |
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| Authors: | Wei Zhan Meng Tong Ling Ji Han Zhang Zemei Ge Xin Wang Runtao Li |
| Affiliation: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
| Abstract: | A continuous-flow synthesis of nitriles by Schmidt reaction has been developed. Using this procedure, a variety of aldehydes could be smoothly transformed into the desired nitriles in good to excellent yields. The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up. |
| Keywords: | Continuous-flow reaction Aldehydes Schmidt reaction Nitriles Safety |
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