A near-infrared fluorescent probe for monitoring fluvastatin-stimulated endogenous H2S production |
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| Authors: | Li-Li Zhang Hui-Kun Zhu Chun-Chang Zhao Xian-Feng Gu |
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| Institution: | a Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China;
b Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China |
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| Abstract: | Most reported fluorescent probes have limitations in practical applications in living systems due to the strong autofluorescence background, construction of probes with near-infrared (NIR) fluorescence emission is an accessible approach for addressing this challenge. We here designed a NIR fluorescent probe for monitoring the endogenous production of H2S in living cells. The designed probe showed significant NIR fluorescence turn-on response to H2S with high selectivity, enabling the sensitive detection H2S. Importantly, the probe could be applied in monitoring the endogenous production of H2S in raw264.7 macrophages. This study showed that fluvastatin can promote the activity of cystathionine γ-lyase (CSE) for generation H2S. |
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| Keywords: | Fluorescent probe Near-infrared fluorescence emission Endogenous H2S detection Fluvastatin |
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