Novel chiral multidentate P3N4-type ligand for asymmetric transfer hydrogenation of aromatic ketones |
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| Authors: | Meng Tao Fang Wu Teng Li Yan-Yun Li Jing-Xing Gao |
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| Institution: | College of Chemistry and Chemical Engineering, and National Engineering Laboratory for Green Chemical Production of Alcohols-Ethers-Esters, Xiamen University, Xiamen 361005, China |
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| Abstract: | Novel chiral multidentate P3N4-type ligand has been synthesized and characterized by NMR and HRMS. Using i-PrOH as solvent and hydrogen source, asymmetric transfer hydrogenation of various ketones was investigated. The catalyst generated in situ from chiral multidentate aminophosphine ligand (R,R,R,R)-3 and IrCl(CO)(PPh3)2 exhibited highly catalytic activity and excellent enantioselectivity under mild conditions, achieving the corresponding chiral alcohols with up to 99% yield and 99% ee. |
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| Keywords: | Chiral aminophosphine ligand Asymmetric catalysis Asymmetric transfer hydrogenation Chiral alcohols Aromatic ketones |
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