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Phenolic constituents from the roots of Alangium chinense |
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| Authors: | Yan Zhang Yun-Bao Liu Yong Li Shuang-Gang Ma Li Li Jing Qu Dan Zhang Jian-Dong Jiang Shi-Shan Yu |
| Institution: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
| Abstract: | Three new phenolics (1-3) and twenty-eight known compounds (4-31) were isolated from an ethanolic extract of roots of Alangium chinense. Compound 11 exhibited antiviral activity against Coxsackie virus B3 with IC50 values of 16.89 μmol/L. Compounds 1, 10-17, 19-21, and 23 showed strong antioxidant activity against Fe2+-cysteine-induced rat liver microsomal lipid peroxidation, with IC50 values of 0.14-8.18 μmol/L. |
| Keywords: | Phenolics Alangium chinense Antiviral Coxsackie virus B3 Antioxidant |
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