99mTc-AMD3100: A novel potential receptor-targeting radiopharmaceutical for tumor imaging |
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| Authors: | Jin Ming Zhang Jia He Tian Tian Ran Li Hai Yu Guo Li Shen |
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| Institution: | a Department of Nuclear Medicine, The PLA General Hospital, Beijing, 100853, China;b Peking University Health Science Center, Beijing, 100191, China |
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| Abstract: | The chemokine CXCR4 receptor is over-expressed in a wide variety of tumors.In this study,AMD3100,which was a prototype non-peptide antagonist of CXCR4 receptor,was labeled with 99mTc.99mTc-AMD3100 was verified by thin layer radio chromatography(TLRC).The tumor-localizing properties of 99mTc-AMD3100 were evaluated and proved in mice bearing Hep-G2 tumor xenograft.99mTc-AMD3100 was a promising,novel receptor-specific radiopharmaceutical with potential application in the imaging of human tumors. |
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| Keywords: | 99mTc Chemokine CXCR4 AMD3100 Tumor imaging |
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