| SOLID-PHASE SYNTHESIS OF 2'—5' OLIGOADENYLATE——2'—5'A CORE |
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| 引用本文： | 何炳林,陈伟朱,刘克良,宗建超,李乃宏.SOLID-PHASE SYNTHESIS OF 2''''—5'''' OLIGOADENYLATE——2''''—5''''A CORE[J].中国科学B辑(英文版),1986(7). |
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| 作者姓名： | 何炳林 陈伟朱 刘克良 宗建超 李乃宏 |
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| 作者单位： | Department of Chemistry，Nankai University，Tianjin，Department of Chemistry，Nankai University，Tianjin，Department of Chemistry，Nankai University，Tianjin，Department of Chemistry，Nankai University，Tianjin，Department of Chemistry，Nankai University，Tianjin |
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| 摘 要： | With phosphotriester approach, the 2'—5' linked oligonucleotide——2'—5'A core was synthesized by using cross-linked polyacrylmorpholide resin as the support and the mesitylene sulfonyl chloride and N-methylimidazole as the condensing agent. Synthesizing the 2'—5'A core with this method has not yet been described. The yields that each of the protected monomers was attached to the polymeric support were satisfactory, i.e., 100%, 60% and 91% respectively.For the synthesis, we improved the methods for preparing the polymeric support and a series of intermediates. For this reason, the yields of the products were markedly increased and the operations to separate the products from the by-products and reagents were simplified.
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