Enantiomer separation and preparation of five organophosphorus compounds and their biological activities |
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Authors: | R Y Gao H F Wang Z Y Chen H Z Yang Q S Wang |
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Institution: | (1) State Key Laboratory of Element-Organic Chemistry, Nankai University, 300071 Tianjin, P.R. China |
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Abstract: | Summary The direct enantiomeric resolution of five O-aryl O-alkyl N-alkyl-phosphoramidothioates was carried out and their pure enantiomers
were prepared on a commercially available Pirkle model chiral column (OA-4700). Absolute configurations of the enantiomers
were determined by circular dichroism (CD) spectroscopy. S-enantiomers were the first compounds to elute chromatographically
and the chromatographic elution order was in accordance with the results of computer simulating calculation. The biological
activity test suggested that all the S-enantiomers were more active than R-enantiomers in killing barnyard grass. |
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Keywords: | Column liquid chromatography Enantiomers Chiral separation Biological activity |
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