Nature's protection racket |
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| Authors: | Micklefield Jason |
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| Institution: | School of Chemistry, University of Manchester, Sackville Street, PO Box 88, Manchester, M60 1QD, UK. |
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| Abstract: | (2S)-4-amino-2-hydroxybutyrate (AHBA) is a side chain that is important for the antibiotic activities of aminoglycosides. The elucidation of the biosynthetic pathway to AHBA, by Spencer et al. in this issue of Chemistry & Biology 1], reveals several surprises and will facilitate biosynthetic engineering of new improved aminoglycoside antibiotics. |
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