Benzotriazolyl-mediated 1,2-shifts of electron-rich heterocycles |
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Authors: | Katritzky Alan R Bobrov Sergey Khashab Niveen Kirichenko Kostyantyn |
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Institution: | Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu |
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Abstract: | The anion formed from the lithiation of 1-(methylthio)methyl]-1H-benzotriazole 1 with n-BuLi adds to heteroaryl ketones to give 2-benzotriazolyl alcohols 3a-m. Thermolysis of 3a-g in the presence of zinc bromide induces a 1,2-shift of heteroaromatic groups to form ketones 4a-g. By contrast, in the rearrangement of 2-benzotriazolyl alcohols 3h,i,k-m migration of the phenyl group rather than the corresponding heteroaromatic groups occurred to give ketones 4h,i,k-m. |
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