A Systematic Study on the Synthesis of n‐Butyl Substituted 8‐Aminoquinolines |
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Authors: | Ahmet Koseoglu Turan Gul Ali Ersin Acar |
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Affiliation: | 1. Department of Chemistry, Bogazici University, Istanbul, Turkey;2. Analytical Biochemistry, Department of Pharmacy, University of Groningen, Groningen, The Netherlands |
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Abstract: | A systematic study on the synthesis of 8‐aminoquinoline derivatives with an n‐butyl group at each alternate position of the quinoline ring was carried out. Skraup Reaction and its Doebner–von Miller variation were used to obtain most of the quinoline ring except for the 2‐butyl‐8‐aminoquinolines and 4‐butyl‐8‐aminoquinolines where the commercially available methylquinoline derivatives were used as precursors. The structures of the synthesized compounds were characterized by FTIR, 1H‐NMR, COSY, 13C‐NMR and HRMS spectra. |
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