Synthesis and Crystal Structure of Novel β‐Lactam Derivatives Bearing Quinoline Moiety via [2 + 2] Cycloaddition |
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| Authors: | Hui Lin Peng Yang Tinghong Fei Fangming Liu |
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| Institution: | 1. College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi, Republic of China;2. College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou, Republic of China |
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| Abstract: | A series of new β‐lactam derivatives 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l were synthesized from 2 + 2] cycloaddition reaction of imines containing quinoline moiety 3a , 3b , 3c , 3d , 3e , 3f with ketene generated in situ from chloroacetyl chloride in dry Et3N. The structures of the prepared compounds were characterized by IR, MS, 1H NMR, and elemental analysis. In addition, the structure of ( 4i ) was determined by single crystal X‐ray crystallography. |
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