Csp2–O and C–C Bond Formation via Pd‐Catalyzed Coupling Reaction of 2,4‐Dichloroquinazoline |
| |
Authors: | Alka Sharma Vijay Luxami Kamaldeep Paul |
| |
Institution: | School of Chemistry and Biochemistry, Thapar University, Patiala, India |
| |
Abstract: | An efficient palladium‐catalyzed C–O and subsequent C–C bond formation of 2,4‐dichloroquinazoline have been described. The designed strategy results in the synthesis of novel 2‐arylated quinazolin‐4‐ones framework with various aryl/heteroaryl boronic acids in moderate to good yields along with 2,4‐diarylated quinazolines. This methodology offers a direct transformation of aryl halides to aryl alcohols/ketone as well as the straight forward application to generate a wide variety of monoaryl and diaryl quinazoline. |
| |
Keywords: | |
|
|