Synthesis and Structure Elucidation of (R)‐3‐(2′‐hydroxyprop‐1‐yl) adenine |
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| Authors: | Yang Gao Jia‐Liang Zhong Tai‐Zhi Wu Lin‐Yong Jin Fu‐Li Zhang |
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| Institution: | 1. Department of Chemical Pharma, Shanghai Institute of Pharmaceutical Industry, Shanghai, China;2. State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai, China |
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| Abstract: | (R)‐3‐(2′‐hydroxyprop‐1‐yl) adenine 4 was obtained by alkylation of adenine 1 with R‐propylene carbonate 2 in the presence of pulverized sodium hydroxide in the synthetic process of tenofovir. The elucidation of the structure of 4 was confirmed by single crystal X‐ray diffraction and NMR experiments such as 1D 1H, 13C, and DEPT, as well as 2D COSY, HSQC, and HMBC spectra. |
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