AgNO3 Catalyzed Regio‐Selective Synthesis of 3‐Alkyl/Aryl‐idene‐3,4‐dihydro‐4‐tosyl‐2H‐1,4‐Benzoxazine: Novel Anti‐Tubercular Scaffolds |
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| Authors: | Sivanandhan Karunanidhi Rajshekhar Karpoormath Milan Bera Rajesh A Rane Mahesh B Palkar |
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| Institution: | 1. Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu‐Natal, Durban, South Africa;2. Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India |
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| Abstract: | A facile and efficient method for the construction of 3‐alkyl/aryl substituted 1,4‐benzoxazine and benzoxazepine via AgNO3 catalyzed cyclization of propargyloxy sulfonamides and their anti‐tubercular activity against Mycobacterium tuberculosis H37RV is described. This cyclization proceeds through 6‐exo‐dig manner to generate the products in moderate to good yields. |
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