Utilization of 2(3H)‐Furanone Bearing a Pyrazolyl Side Chain for the Construction of a Variety of Thiazolidinone Derivatives |
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| Authors: | Wael S. I. Abou‐Elmagd Ahmed I. Hashem |
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| Affiliation: | Chemistry Department, Faculty of Science, Ain Shams University, Abassia, Cairo, Egypt |
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| Abstract: | 2(3H)‐Furanone 1 was utilized for the construction of thiazolidinone derivatives. Thus, upon treatment the cyano derivatives 5 with thioglycolic acid afforded the thiazolidinone derivatives 6 . Reaction of the Schiff base derivative 9 with thioglycolic acid gave the thiazolidinone derivative 10 . Decomposition of the azides 11 in dry benzene in the presence of thioglycolic acid gave the thiazolidindione derivative 12 . Antimicrobial activities of synthesized compounds were tested. Some of the tested compounds showed promising activities. |
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