Synthesis and Reactivity of Enaminones: A Facile Synthesis of Thiophene and 1,3,4‐Thiadiazole Derivatives Incorporating a Thiazole Moiety |
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| Authors: | Kamal M Dawood Samia M Sayed |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt;2. Department of Chemistry, Faculty of Science, Aswan University, Aswan, Egypt |
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| Abstract: | Several new heterocyclic compounds such as thiophene derivatives have been synthesized by the reactions of the versatile unreported 3‐mercapto‐2‐(4‐methyl‐2‐(tosylamino)thiazole‐5‐carbonyl)‐3‐phenylaminopropenal ( 7 ) with chloroacetonitrile, ethyl 2‐bromoacetate, and 1‐aryl‐2‐bromoethanone derivatives. Reaction of potassium salt intermediate 6 with hydrazonyl halides ( 14a , 14b , 14c ) to afford 1,3,4‐thiadiazole derivatives incorporating a thiazole moiety has been described. All newly synthesized compounds were elucidated by considering the data of both elemental and spectral analysis. |
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