Synthesis of 3‐aminomethylidenechroman‐2‐carboxamides by a Sequential One‐pot Three Component Reaction and by Post‐Passerini Condensation Modification |
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| Authors: | Jaydip Ghosh Suman Kalyan Panja Sourav Maiti Pritam Biswas Tapas Sarkar Chandrakanta Bandyopadhyay |
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| Affiliation: | 1. Department of Chemistry, R. K. Mission Vivekananda Centenary College, Kolkata, West Bengal, India;2. CSIR Indian Institute of Chemical Biology, Chemistry Division, Jadavpur, West Bengal, India |
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| Abstract: | 3‐Arylaminomethylidenechroman‐2‐carboxamide has been synthesized by a one‐pot three component reaction among 3‐formylchromone, aromatic amine, and cyclohexyl isocyanide. 3‐(N‐alkylsubstitued/unsubstituted)aminomethylidenechroman‐2‐carboxamides were synthesized by heating Passerini products derived from chromone‐3‐carbaldehyde with different aliphatic primary amines. The products obtained from the reactions of aliphatic primary amines readily form chromeno[2,3‐c]pyrrole when heated in acetic acid. Bischromanones have also been synthesized using this methodology. |
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