Simple Synthesis of 3‐Oxopropanenitriles via Electrophilic Cyanoacetylation of Heterocycles with Mixed Anhydrides |
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| Authors: | Anita Andicsovà‐Eckstein Erika Kozma Daniel Végh |
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| Institution: | 1. Polymer Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic;2. Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Milano, Italy;3. Institute of Organic Chemistry, Slovak University of Technology, Bratislava, Slovak Republic |
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| Abstract: | A simple and efficient method for the synthesis of 3‐oxopropanenitriles from variously substituted heterocyclic compounds via direct electrophilic cyanoacetylation is described. A series of heterocyclic 3‐oxopropanenitriles ( 2a , 2b , 2c , 2d , 2e , 2f , 2g , 2h , 2i , 2j , 2k ) have been synthesized using mixed anhydride (acetic or trifluoroacetic anhydride:cyanoacetic acid) in the presence of Mg(ClO4)2·2H2O as catalyst. This method can be extended also for the cyanoacetylation of electron poor aromatic compounds. |
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