Ultrasound Assisted Synthesis of Some Novel Bis‐Pyridazine Derivatives |
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Authors: | Ahmed E M Mekky Abdullah S Al‐Bogami |
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Affiliation: | 1. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia;2. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt |
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Abstract: | Bis‐enaminone 3 was coupled with aryldiazonium chlorides 4a , 4b to afford the bis‐arylhydrazonopropanals 6a , 6b . Compounds 6a , 6b could be utilized for the synthesis of a variety of bis‐(dimethyl 2,3‐dihydropyridazine‐3,4‐dicarboxylate), bis‐(pyridazin‐3(2H)‐one), bis‐(2,3‐dihydropyridazine‐4‐carbonitrile) and bis‐(3‐imino‐2,3‐dihydropyridazine) derivatives, under ultrasonic irradiation. A comparative study of aforementioned reactions was carried out under conventional method as well as under ultrasonic irradiation conditions. |
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