Asymmetric Cycloaddition: An Efficient Synthesis of Enantiopure Isoxazolines Substituted with Carbohydrate Analogues |
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| Authors: | Omar K. Al‐Duaij Naoufel Ben Hamadi Lotfi Khezemi |
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| Affiliation: | 1. Chemistry Department, College of Science, IMSIU (Al‐Imam Mohammad Ibn Saud Islamic University), Riyadh, Saudi Arabia;2. Laboratory of Synthesis Heterocyclic and Natural Substances, Faculty of Sciences of Monastir, Boulevard of Environment, Monastir, Tunisia |
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| Abstract: | A simple and convenient method for the synthesis of heterocycles substituted with carbohydrate analogs is described. The chiral optically pure five‐membered glycoconjugates containing the isoxazoline unit were obtained by an aromatic nitrile oxides cycloaddition with 1‐phenyl‐1,2‐dihydro‐pyridazine‐3,6‐dionyl N‐glycoside derivatives. |
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| Keywords: | Asymmetric cycloaddition aromatic nitrile oxides carbohydrate isoxazoline |
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