A Simple Green Protocol for the Condensation of Anthranilic Hydrazide with Cyclohexanone and N‐Benzylpiperidinone in Water |
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| Authors: | Ferenc Miklós Ferenc Fülöp |
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| Institution: | 1. Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;2. Stereochemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary |
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| Abstract: | An environmentally benign condensation of anthranilic hydrazide with cyclohexanone or N‐benzylpiperidin‐4‐one in aqueous medium has been developed for the synthesis of benzoylhydrazones A. The thermal rearrangements of hydrazones A yielded 3′‐aminospiro‐quinazolinones B. When A or B was reacted repeatedly with cyclohexanone or N‐benzylpiperidin‐4‐one, spiroquinazoline‐hydrazones C were formed. From aqueous suspensions, products could be isolated in high purity by simple filtration. |
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