Convenient Synthesis of Novel Quinazoline Congeners via Copper Catalyzed C–N/C–S Coupling and Their Biological Evaluation |
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| Authors: | Harshad P Lakum Dhruvin R Shah Kishor H Chikhalia |
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| Institution: | Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India |
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| Abstract: | A library of novel quinazoline scaffolds endowed with semicarbazide/oxadiazole thiol motif synthesized via an efficient and sustainable copper catalyzed C–N/C–S coupling is reported, making the presented methodology extremely valuable from economic and environmental point of view. Among the all synthesized compounds screened for in vitro antibacterial, antifungal, and anti‐TB activity, 7b , 7c , 7f , 9b , 9c , 9i , and 9j showed excellent inhibitory effect on particular strain of bacteria, fungi, and M. tuberculosis H37Rv as well. All the newly synthesized derivatives were well characterized by their IR, 1H NMR, 13C NMR, mass spectroscopy as well as elemental analysis. |
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