Synthesis,Antiviral, and Antimicrobial Activity of N‐ and S‐Alkylated Phthalazine Derivatives |
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| Authors: | Ahmed H Moustafa Hassan A El‐Sayed Rasha A Abd El‐Hady Abdelfattah Z Haikal Maher El‐Hashash |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt;2. Department of Chemistry, Faculty of Science, Ain‐Shams University, Cairo, Egypt |
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| Abstract: | A series of N‐alkylphthalazinone were synthesized by the reaction of phthalazin‐1(2H)‐one derivatives 1a , 1b , 1c with alkylating agents namely, propargyl, allyl bromide, epichlorohydrin, 1,3‐dichloro‐2‐propanol, 4‐bromobutylacetate, and 1‐(bromomethoxy)ethyl acetate to give the corresponding N‐alkylphthalazinone 2a , 2b , 2c , 3a , 3b , 3c , 5a , 5b , 5c , 6a , 6b , 6c , 7a , 7b , 7c , and 9a , 9b , 9c . Alkylation of phthalazin‐1(2H)‐thione to give a series from S‐alkylphthalazine 12 , 13 , 14 and thioglycosides 15 and 17 was performed. Deprotection of compounds 7a , 7b , 7c , 9a , 9b , 9c , 15 , and 17 resulted in the formation of the corresponding products 8a , 8b , 8c , 10a , 10b , 10c , 16 , and 18 . The structure of newly synthesized compounds was assigned by IR, 1H, 13C NMR, and elemental analysis. Some of these compounds were screened for antiviral and antimicrobial activity. |
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