Synthesis and In Vitro Antitumor Activity of New Isoxazolo[5,4‐d]Pyrimidine Systems |
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Authors: | Wafaa S Hamama Mona E Ibrahim Hanafi H Zoorob |
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Institution: | Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt |
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Abstract: | The reaction of 5‐amino‐3‐methylisoxazole ( 1 ) with aldimines 2 , 3 , 4 , 5 , 6 , 7 gave basic side chain 5‐amino‐3‐methylisoxazole derivatives 8 , 9 , 10 , 11 , 12 , 13 . Annulations of derivatives 8 , 9 , 10 , 11 , 12 , 13 with anisaldehyde afforded the target isoxazolo5,4‐d]pyrimidines 14 , 15 , 16 , 17 . Treatment of 1 with isatin ketimine anil 18 resulted in the formation of derivative 19 , which further cyclized with anisaldehyde afforded the spirotetracyclic system 20 . Mannich reaction of 1 with primary amine such as methylamine and benzylamine gave the corresponding isoxazolo5,4‐d]pyrimidine derivatives 21 and 22 , respectively. The newly synthesized compounds were tested for their antitumor activity. |
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