| DNA damage induced by laser-hematoporphyrin derivative |
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| 作者姓名： | Enhua Cao Fengying Chen Shumin Xin |
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| 作者单位： | Institute of Biophysics，Academia Sinica，Beijing 100101，China |
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| 摘 要： | Irradiation caused DNA single-strand breaks in S180 cells in the presence oflaser-hematoporphyrin derivative(HPD).The number of single strand breaks was 3.69 ×10~(10)break dolton~(-1).The analysis of base composition of DNA showed that the effect of laser-HPDirradiation on guanine was the highest,being 5-12 times as high as those of the three others(adenine,cytosine and thymine).It was different from the nature of DNA damage caused by γ-ray irradiation.
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| 收稿时间： | 1992/2/17 |
DNA damage induced by laser-hematoporphyrin derivative |
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| Enhua Cao,Fengying Chen,Shumin Xin.DNA damage induced by laser-hematoporphyrin derivative[J].中国激光(英文版),1992,1(4):379-384. |
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| Authors: | Enhua Cao Fengying Chen Shumin Xin |
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| Abstract: | Irradiation caused DNA single-strand breaks in S180 cells in the presence oflaser-hematoporphyrin derivative(HPD).The number of single strand breaks was 3.69 ×10~(10)break dolton~(-1).The analysis of base composition of DNA showed that the effect of laser-HPDirradiation on guanine was the highest,being 5-12 times as high as those of the three others(adenine,cytosine and thymine).It was different from the nature of DNA damage caused by γ-ray irradiation. |
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| Keywords: | laser hematoporophyrin derivative DNA single-strand break photosensiti- zation S180 cell |
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