Total synthesis of dysiherbaine |
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Authors: | Phillips Dean Chamberlin A Richard |
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Affiliation: | Department of Chemistry, University of California, Irvine 92697-2025, USA. |
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Abstract: | A convergent total synthesis of the marine natural product dysiherbaine was accomplished. The key steps of the synthesis are an alkylation at the gamma-carbon of a protected glutamate with a highly substituted pyran derived from mannose, which was followed by a ring-contraction cascade reaction, which simultaneously gave the tetrasubstituted carbon and the hexahydrofuro[3,2-b]pyran ring system of the natural product. |
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