| Synthesis and in vitro-Anti-hepatitis B Virus Activities of Several Ethyl 5-Hydroxy-lH-indole-3-carboxylates |
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| 作者姓名： | ZHAO Chun-shen ZHAO Yan-fang CHAI Hui-fang GONG Ping |
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| 作者单位： | Liaoning Province Key Laboratory of Innovative Medicine Research and Design, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China |
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| 基金项目： | Supported by the National Natural Science Foundation of China（ No. 20042047）. |
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| 摘 要： | A series of ethyl 5-hydroxyindole-3-earboxylates 6a-10r was designed and synthesized. The structures of all the compounds were confirmed by IR, ^1H NMR, and MS and their anti-hepatitis B virus （HBV） activities were evaluated in 2.2.15 cells. Among them, compound 7g { ethyl 5-hydroxy-2- （ 3-methoxyphenylsulfinyl ） methyl ] -1-methyl-4- （4-methylpiperazin-1-yl） methyl ]-1H-indole-3-carboxylate} displays a significant anti-HBV activity, which is more potent than the positive control lamivudine.
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| 关 键 词： | 乙烷基5-羟基-1H-吲哚-3-羧酸酯 合成 抗乙型肝炎病毒活性 结构分析 |
| 文章编号： | 1005-9040（2006）-05-577-07 |
| 收稿时间： | 2005-10-10 |
Synthesis and in vitro-Anti-hepatitis B Virus Activities of Several Ethyl 5-Hydroxy-1H-indole-3-carboxylates |
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| ZHAO Chun-shen ZHAO Yan-fang CHAI Hui-fang GONG Ping.Synthesis and in vitro-Anti-hepatitis B Virus Activities of Several Ethyl 5-Hydroxy-lH-indole-3-carboxylates[J].Chemical Research in Chinese University,2006,22(5):577-583. |
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| Authors: | Chun-shen ZHAO Yan-fang ZHAO Hui-fang CHAI Ping GONG |
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| Institution: | aLiaoning Province Key Laboratory of Innovative Medicine Research and Design, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China |
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| Abstract: | |
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| Keywords: | Ethyl 5-hydroxy-1H-indole-3-carboxylates Synthesis Anti-hepatitis B virus activity |
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