Templating effects in aristolochene synthase catalysis: elimination versus cyclisation |
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| Authors: | Faraldos Juan A González Verónica Senske Michael Allemann Rudolf K |
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| Institution: | School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom. |
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| Abstract: | Analysis of the products generated by mutants of aristolochene synthase from P. roqueforti (PR-AS) revealed the prominent structural role played by the aliphatic residue Leu 108 in maintaining the productive conformation of farnesyl diphosphate to ensure C1-C10 (σ-bond) ring-closure and hence (+)-aristolochene production. |
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