Phytochemical investigation characterisation and anticonvulsant activity of Ricinus communis seeds in mice |
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| Authors: | Tripathi Avinash Chandra Gupta Rajiv Saraf Shailendra K |
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| Institution: | Faculty of Pharmacy, Northern India Engineering College, Lucknow, UP, India. |
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| Abstract: | The ethanol extract of the dried, powdered hull portion of Ricinus communis seeds indicated the presence of alkaloids, steroids, flavonoids, glycosides and phenolics, amongst others. Ricinine was isolated as an active constituent and characterised by various chemical and spectroscopic techniques. The anticonvulsant activity of the isolated compound was evaluated in mice using the maximal electroshock (MES) model. The isolated compound at a dose of 60?mg?kg?1 body weight, orally, significantly (p?
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