Regulation of the lumen of a resistance blood vessel by mechanical stimuli |
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Authors: | V A Buchin N Kh Shadrina |
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Institution: | (1) Institut de Pharmacologie Mol?culaire et Cellulaire, CNRS-UMR6097, 660 route des Lucioles, Sophia Antipolis, 06560, France;(2) KU Leuven, Department Mol Cell Biology, Laboratory Ion Channel Research, Campus Gasthuisberg, O&N 1, Herestraat 49-Bus 802, 3000 Leuven, Belgium; |
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Abstract: | The flow in a vessel able to regulate its lumen under the action of mechanical stimuli, the variation of the pressure difference
between the inner and outer surfaces of the vessel wall and the blood flow velocity, is described. This ability is determined
by the effect of the mechanical stimuli on the degree of activation of smooth muscle cells in the vessel wall. In order to
describe the active properties of the wall, two controlling parameters which have the sense of the concentration of free calcium
ions in the cytoplasm of smooth muscle cells and the average concentration of nitric oxide in the smooth muscle layer, are
introduced. The approach proposed makes it possible to estimate both the degree of participation of each mechanical stimulus
in vessel lumen regulation and the result of interaction of two differently directed vascular responses. The calculations
show that both the magnitude and direction of the radius response to a mechanical stimulus depend on the initial state of
the vessel wall. The role of the vessel wall sensitivity to mechanical stimuli in the stabilization of the blood flow-rate
and the variation of the radius along the vessel is considered. |
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