Hydrogenation of dehydroamino acids in the presence of palladium(II) complexes with methionine |
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| Authors: | I N Lisichkina A I Vinogradova M B Saporovskaya V K Latov V M Velikov |
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| Institution: | 1. A. N. Nesmeyanov Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow
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| Abstract: | | 1. |
The catalytic system obtained upon the reaction of S- and R-MetHPdCl2 with H2 or NaBH4 has high catalytic activity in the hydrogenation of cinnamic acid derivatives, but the enantioselectivity of this reaction does not exceed 3–3.4%.
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The hydrogenation of N-Ac-APhe-S-Tyr in the presence of both R- and S-MetHPdCl2 leads to a product with an 18–24% diastereomeric excess of the R, S isomers.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1170–1172, May, 1988. |
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