6-Membered ring intermediates in polymerization of N-carboxyanhydride-L-α-arginine in H_2O |
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基金项目: | Supported by the Special Research Project of Beijing Scientific and Technical Committee (Grant No. Z00063002040191);;the Natural Basic Research Program of China (Grant No. 2007CB935901) |
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摘 要: | In polymerization of N-carboxyanhydride-L-α-arginine(L-Arg-NCA) in H2O,nucleophilic reaction of guanidine group with the carbonyl group of L-Arg-NCA leads to quick intramolecular rearrangement,yielding a 6-membered ring intermediate 1-amidino-3-amino-2-piperidone,which is either elongated by another L-Arg-NCA yielding arginyl-1-amidino-3-amino-2-piperidone or hydrolyzed to L-α-arginine.The oligoarginines are formed mainly through hydrolysis of arginyl-1-amidino-3-amino-2-piperidones.This is a unique pathway...
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关 键 词: | N-carboxyanhydride L-Arg-NCA intermediates L-α-arginine polymerization |
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